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Severe Combined Immunodeficiency

Showing 1 - 25 of >10,000
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Genetic Basis of Immunodeficiency

Recruiting
  • Severe Combined Immunodeficiency
    • Bethesda, Maryland
      National Institutes of Health Clinical Center
    Jan 21, 2023

    The Experience of Screening for SCID

    Recruiting
    • Severe Combined Immunodeficiency
    • SCID Screening
    • London, United Kingdom
      King's College London
    Dec 6, 2022

    Severe Combined Immunodeficiency Disease, X-linked Trial in San Francisco, Memphis, Seattle (genetic, drug, device)

    Recruiting
    • Severe Combined Immunodeficiency Disease, X-linked
    • CL20-i4-EF1α-hγc-OPT
    • +2 more
    • San Francisco, California
    • +2 more
    Jan 9, 2023

    X-linked Severe Combined Immunodeficiency (XSCID) Trial run by the National Institute of Allergy and Infectious Diseases (NIAID)

    Suspended
    • X-linked Severe Combined Immunodeficiency (XSCID)
    • Bethesda, Maryland
      National Institutes of Health Clinical Center, 9000 Rockville Pi
    Aug 24, 2022

    Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency Trial in Paris (ARTEGENE drug product)

    Not yet recruiting
    • Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency
    • ARTEGENE drug product
    • Paris, France
      Department of Pediatric Immunology, Hematology and Rheumatology
    Sep 26, 2022

    Severe Combined Immunodeficiency, X-Linked Trial in London (Lentiviral vector transduced CD34+ cells)

    Recruiting
    • Severe Combined Immunodeficiency, X-Linked
    • Lentiviral vector transduced CD34+ cells
    • London, Greater London, United Kingdom
      Great Ormond Street Hospital for Children NHS Foundation Trust
    Mar 15, 2022

    Neonatal Screening of Severe Combined Immunodeficiencies

    Completed
    • Severe Combined Immunodeficiency
    • Neonatal Screening
      • Shanghai, Shanghai, China
        Children's Hospital of Fudan University
      Jan 3, 2022

      X-linked Severe Combined Immunodeficiency Trial in Paris (Gene transfer)

      Completed
      • X-linked Severe Combined Immunodeficiency
      • Gene transfer
      • Paris, France
        Hopital Necker
      Sep 22, 2021

      Severe Combined Immunodeficiency Due to ADA Deficiency Trial in Milan (STRIMVELIS)

      Completed
      • Severe Combined Immunodeficiency Due to ADA Deficiency
      • Milan, Italy
        Ospedale San Raffaele - Telethon Institute for Gene Therapy (OSR
      Feb 18, 2022

      Severe Combined Immunodeficiency, X Linked, Gene Therapy Trial in United Kingdom, United States (autologous CD34+ cell

      Recruiting
      • Severe Combined Immunodeficiency, X Linked
      • Gene Therapy
      • autologous CD34+ cell transduced with G2SCID vector
      • Los Angeles, California
      • +4 more
      Jul 19, 2022

      Severe Combined Immune Deficiency (SCID) Trial run by the National Institute of Allergy and Infectious Diseases (NIAID)

      Enrolling by invitation
      • Severe Combined Immune Deficiency (SCID)
      • Bethesda, Maryland
        National Institutes of Health Clinical Center
      Aug 24, 2022

      Severe Combined Immunodeficiency Trial in Memphis (drug, device, other)

      Recruiting
      • Severe Combined Immunodeficiency
      • Anti-thymocyte globulin (rabbit)
      • +5 more
      • Memphis, Tennessee
        St. Jude Children's Research Hospital
      Oct 6, 2021

      Severe Combined Immunodeficiency Trial in San Francisco (AProArt, CliniMACS® CD34 Reagent System cell sorter device, Busulfan)

      Recruiting
      • Severe Combined Immunodeficiency
      • San Francisco, California
        University of California, San Francisco (UCSF) Children's Hospit
      Feb 4, 2022

      Haematological Malignancy, Acute Leukemia, MDS Trial in Lyon (Physical activity program)

      Not yet recruiting
      • Haematological Malignancy
      • +5 more
      • Physical activity program
      • Lyon, France
        Institut d'Hématologie et d'Oncologie Pédiatrique
      Mar 25, 2022

      Severe Combined Immunodeficiency Due to RAG1 Deficiency Trial in Leiden (Gene therapy)

      Recruiting
      • Severe Combined Immunodeficiency Due to RAG1 Deficiency
      • Gene therapy
      • Leiden, Netherlands
        Leiden University Medical Center
      Dec 3, 2021

      Patients Previously Treated With Autologous ex Vivo Gene Therapy

      Enrolling by invitation
      • Adenosine Deaminase Deficiency
      • Severe Combined Immunodeficiency (SCID)
      • autologous ex vivo gene therapy products based on the EFS LV encoding for the human adenosine deaminase (ADA) gene (EFS-ADA LV)
      • Los Angeles, California
      • +1 more
      Mar 31, 2022

      Retroviral Insertion Site Analysis in Strimvelis Gene Therapy

      Enrolling by invitation
      • Severe Combined Immunodeficiency Due to ADA Deficiency
      • Retroviral Insertion Site Analysis
      • Milan, Italy
        Ospedale San Raffaele - Telethon Institute for Gene Therapy (OSR
      Feb 17, 2022

      Evaluation of Patients With Immune Function Abnormalities

      Recruiting
      • Chronic Granulomatous Disease (CGD)
      • +3 more
        • Bethesda, Maryland
          National Institutes of Health Clinical Center, 9000 Rockville Pi
        Aug 24, 2022

        Haematological Malignancy, Acute Leukemia, MDS Trial in Lyon (Physical activity program)

        Withdrawn
        • Haematological Malignancy
        • +5 more
        • Physical activity program
        • Lyon, France
          Institut d'Hématologie et d'Oncologie Pédiatrique
        Feb 10, 2022

        Immune Deficiency Disorders, Severe Combined Immunodeficiency, Chronic Granulomatous Disease Trial in Saint Louis (Transplant

        Recruiting
        • Immune Deficiency Disorders
        • +13 more
        • Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
        • Saint Louis, Missouri
          Washington University
        Apr 25, 2022

        Severe Combined Immunodeficiency Due to ADA Deficiency Trial in London (Infusion of autologous cryopreserved EFS-ADA LV CD34+

        Active, not recruiting
        • Severe Combined Immunodeficiency Due to ADA Deficiency
        • Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101)
        • +2 more
        • London, United Kingdom
          Great Ormond Street Hospital for Children NHS Foundation Trust
        Dec 17, 2021

        Immunologic Deficiency Syndromes Trial in Milano (Strimvelis)

        Enrolling by invitation
        • Immunologic Deficiency Syndromes
        • Strimvelis
        • Milano, Lombardia, Italy
          Orchard Investigational Site
        Jun 23, 2021

        Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified, Severe Chronic

        Enrolling by invitation
        • Severe Combined Immunodeficiency (SCID)
        • +8 more
        • CD3/CD19 negative allogeneic hematopoietic stem cells
        • Pittsburgh, Pennsylvania
          Children's Hospital of Pittsburgh of UPMC
        Dec 6, 2021

        Adenosine Deaminase Severe Combined Immune Deficiency Trial (A cryopreserved formulation of autologous mPB CD34+ hematopoietic

        Not yet recruiting
        • Adenosine Deaminase Severe Combined Immune Deficiency
        • A cryopreserved formulation of autologous mPB CD34+ hematopoietic stem and progenitor cells transduced ex vivo with the EFS-ADA lentiviral vector encoding the human ADA enzyme
        • (no location specified)
        Jun 20, 2022

        Patients Who Have Received Gene Therapy Or Gene Marked Products

        Recruiting
        • Severe Combined Immunodeficiency
        • +4 more
        • Venipuncture
        • Memphis, Tennessee
          St. Jude Children's Research Hospital
        Dec 10, 2021